Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy
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چکیده
منابع مشابه
SOCS3 is involved in cardiomyocyte hypertrophy induced by Ang II
This study is to explore the effects of two Suppressors of Cytokine Signalling (SOCS) members, namely SOCS-1 and -3, on the regulation of cardiomyocyte hypertrophic response induced by Angiotensin-2 (AngII). Rat neonatal cardiomyocytes culture were cultured and treated with Angiotensin II. After SOCS1 and SOCS3 inhibition by si-RNA transfection, the cellular hypertrophic response indicated by c...
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BACKGROUND/AIMS Studies performed in experimental animals have shown that polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy. This involves an increase in ornithine decarboxylase (ODC) activity and intracellular polyamines associated with regulation of gene expression. Difluoromethylornithine (DFMO), an irreversible inhibitor of ODC, has att...
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Buckwheat rutin has been found to be able to inhibit angiotensin II (AngII) - induced hypertrophy in cultured neonatal rat cardiomyocytes, but the mechanism remains uncertain. In this study, myocardial hypertrophy model was made by adding AngII to the medium of cardiac myocytes of neonatal rats, meanwhile, different concentrations of buckwheat rutin were applied to observe their effects. Intrac...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.14.9760